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| Two postdoctoral positions are available in the group of Roger Williams. One position focuses on the biogenesis of multivesicular endosomes in lysosomal sorting. You will make a significant contribution to a research programme that will unravel the biogenesis of the multivesicular body and reconstitute this organelle in vitro. The research programme is a multidisciplinary approach involving structural and biophysical approaches. Previous experience with X-ray crystallography,protein chemistry, protein folding, enzymology, biophysical methods and cell biology are desirable.
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| The other position focuses on the molecular biology of phosphoinositide 3-kinases. Our interest is the roles of the class I and III isoforms in cell signaling and protein sorting. The project involves applying crystallographic, mass spectroscopic and other biophysical methods to study the structures of regulatory complexes, the mechanism of catalysis and the manner in which these enzymes select their substrates in cellular membranes.
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| You will be awarded a 2.5 year MRC Career Development Fellowship,which is a training and development position for a postdoctoral scientist who has recently completed her or his doctoral studies or is moving into a new research discipline. The closing date for the position is 2 January 2009.
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| For informal enquiries,please contact Roger Williams,email: rlw@mrc-lmb.cam.ac.uk website: http://www2.mrc-lmb.cam.ac.uk/PNAC/Williams_R/
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| Applications for this post must be made online at
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| http://jobs.mrc.ac.uk inputting the reference number LMB08/687.
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| Please include a CV and covering letter with your application.
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| Recent publications from the group relevant to the research programme:
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| Obita, T., Saksena, S., Ghazi-Tabatabai, S., Gill, D. J., Perisic, O., Emr, S. D. & Williams, R. L. (2007) Nature 449, 735-739
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| Ghazi-Tabatabai, S., Saksena, S., Short, J. M., Pobbati, A. V., Veprintsev, D. B., Crowther, R. A., Emr, S. D., Egelman, E. H. & Williams, R. L. (2008) Structure 16, 1345-1356
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| Samson, R. Y., Obita, T., Freund, S. M., Williams, R. L. & Bell, S. D. (2008) Science Express online.
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| Miled, N., Yan, Y., Hon, W.C., Perisic, O., Zvelebil, M., Inbar, Y. , Schneidman-Duhovny, D., Wolfson, H.J., Backer,J.M. Williams, R.L. (2007) Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science 317:239-242.
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