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Experimental phasing: Difference between revisions
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Maximum likelihood phasing in CNS appeared to my recollection shortly after SHARP and has a perfectly decent implementation that has solved many structures and produces excellent maps. It has an excellent web-based interface, good on-line help, and very good example scripts. | Maximum likelihood phasing in CNS appeared to my recollection shortly after SHARP and has a perfectly decent implementation that has solved many structures and produces excellent maps. It has an excellent web-based interface, good on-line help, and very good example scripts. | ||
* | * [http://solve.lanl.gov/Solve/solve.html SOLVE] | ||
SOLVE was the first truly automated experimental phasing pipeline in the second half of the '90s. Its worth mentioning also in this section, since it uses a number of ingenious solutions to the phasing problem, e.g. correlated phasing, that produce phases of excellent quality and can easily be used just for phasing outside its own pipeline. | SOLVE was the first truly automated experimental phasing pipeline in the second half of the '90s. Its worth mentioning also in this section, since it uses a number of ingenious solutions to the phasing problem, e.g. correlated phasing, that produce phases of excellent quality and can easily be used just for phasing outside its own pipeline. | ||
* | * [http://shelx.uni-ac.gwdg.de/SHELX SHELXE] | ||
SHELXE is again mostly used in the context of the SHELX suite and the HKL2MAP pipeline but is an excellent stand alone solution as well. Its peculiarity is the combination of phasing and density modification tricks in a very quick iterative fashion, and it can produce excellent results. | SHELXE is again mostly used in the context of the SHELX suite and the HKL2MAP pipeline but is an excellent stand alone solution as well. Its peculiarity is the combination of phasing and density modification tricks in a very quick iterative fashion, and it can produce excellent results. | ||